viernes, 29 de noviembre de 2013

Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function - González-Bulnes - 2013 - Angewandte Chemie International Edition - Wiley Online Library

Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function - González-Bulnes - 2013 - Angewandte Chemie International Edition - Wiley Online Library

Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function

  1. Luis González-Bulnes1,†,
  2. Ignacio Ibáñez2,3,†,
  3. Dr. Luis M. Bedoya4,
  4. Manuela Beltrán4,
  5. Dr. Silvia Catalán2,3,
  6. Dr. José Alcamí4,*,
  7. Prof. Santos Fustero2,3,*,
  8. Dr. José Gallego1,*
Article first published online: 25 NOV 2013
DOI: 10.1002/anie.201309856
Thumbnail image of graphical abstract Bilaterally substituted p-terphenyl molecules reproduce the interactions of an α-helix of the HIV-1 protein Rev with its RNA receptor and block Rev function and virus replication. In their Communication (DOI: 10.1002/anie.201306665), J. Alcamí, S. Fustero, and J. Gallego et al. report the structure-based design of terphenyl molecules that inhibit the Rev-mediated transport of HIV-1 RNA from the nucleus to the cytoplasm by binding to the RNA loop that is recognized by Rev (image prepared with the help of M.C. Ibáñez).

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